Covid-19 vaccine trial recruitment

[Anastasius]

I notice that Synexus are recruiting for the Phase 3 trial of the vaccine from Novavax. Does depend on where you live though.

https://www.synexusclinic.co.uk. Filter by "immunisation & vaccination"

[teamsaint]

I notice that Synexus are recruiting for the Phase 3 trial of the vaccine from Novavax. Does depend on where you live though.

https://www.synexusclinic.co.uk. Filter by "immunisation & vaccination"

A doctor was suggesting paying people to get vaccinated the other day.Can’t / haven’t get my head round the moral implications, but I won’t be accepting money to have one, that is for sure.

[Dave2002]

Requirements:

If you meet the following requirements, you may be eligible to participate in a clinical trial:

Age 18 years or older
Have not been infected with COVID-19

I thought we are now at a time when many people just don't know whether they have ever been infected with Covid-19.

[Anastasius]

A doctor was suggesting paying people to get vaccinated the other day.Can’t / haven’t get my head round the moral implications, but I won’t be accepting money to have one, that is for sure.

In the general scheme of things I'd agree with you that paying to get vaccinated opens up a whole can of worms. Will people then expect to be paid for their children to have an MMR jab. I agree with you. It does seem wrong. Trouble is Covid is such a 'unique' virus and a law unto itself that perhaps anything that encourages people to avoid catching it or passing it on has to be a good thing?

Anyway, I just flagged this up for people to take the opportunity or not as the case may be.

My own take is that I don't see it as a replacement for social distancing, masks when/where necessary, washing hands and generally avoiding contact with others. I may not even get the vaccine but a placebo. The vaccine may not be that good but there is always the chance that it is and so forms a second line of defence.

[Dave2002]

A big snag with vacccine trials for this disease is that many of the people who might need protection are elderly, but they might be unwilling to take part in a trial - for fairly obvious reasons.

Younger people might feel more inclined to try, though they are statistically less likely to be affected by the disease.

[Cockney Sparrow]

I've seen a segment on TV, a few weeks ago. What were they injecting? - I'm not sure - it was Covid related for sure. It took place where the volunteers were monitored constantly, with nurses and doctor(s) present in a facility where they stayed for at least 24 hours. Apparently the rules were revamped after the Northwick Park incident.

The Synexus website covers a wide range of drug/other trials. I'd be surprised if this was refers to a cohort of volunteers who turn up, receive the vaccine and go home, albeit with contact on a regular basis afterwards.

[Serial_Apologist]

A big snag with vacccine trials for this disease is that many of the people who might need protection are elderly, but they might be unwilling to take part in a trial - for fairly obvious reasons.

As one who falls into the latter category, I would be prepared to put myself forward, provided the scheme had been going for a good month, and reports were that it was safe.

[oddoneout]

A doctor was suggesting paying people to get vaccinated the other day.Can’t / haven’t get my head round the moral implications, but I won’t be accepting money to have one, that is for sure.

It seems to me that the global rush to get a vaccine 'out there' is perhaps resulting in things being done differently. High numbers are needed quickly to establish safety and efficacy, and payment might be one way to achieve that. It could also be argued that since early adopters would in effect be guinea pigs who in other circumstances would be paid as part of lengthier clinical trials then payment should be made anyway.

[Dave2002]

As one who falls into the latter category, I would be prepared to put myself forward, provided the scheme had been going for a good month, and reports were that it was safe.

Your constraints probably mean that in practice it would be at least 4-6 months in from the start of the trial, possibly longer. Is it possible to seriously establish safety within 3 months? Also, what might be considered safe for a 30 year old fit person may be less appropriate for a 70+ year old with medical problems. It may not be so easy to extrapolate from younger people to older ones, though that of course is what is likely to happen. Some older people who are perhaps already ill may feel public spirited, and go for it on the grounds that they possibly won't get a lot worse, and they may feel they've not got so much to lose. It'd be quite interesting to know what would motivate people in different groups to put themselves forward.

[Anastasius]

A big snag with vacccine trials for this disease is that many of the people who might need protection are elderly, but they might be unwilling to take part in a trial - for fairly obvious reasons.

Younger people might feel more inclined to try, though they are statistically less likely to be affected by the disease.

Which is why I've flagged it up here as I thought - rightly or wrongly - that the demographics of the forum was right in their target participants !

[Anastasius]

I've seen a segment on TV, a few weeks ago. What were they injecting? - I'm not sure - it was Covid related for sure. It took place where the volunteers were monitored constantly, with nurses and doctor(s) present in a facility where they stayed for at least 24 hours. Apparently the rules were revamped after the Northwick Park incident.

The Synexus website covers a wide range of drug/other trials. I'd be surprised if this was refers to a cohort of volunteers who turn up, receive the vaccine and go home, albeit with contact on a regular basis afterwards.

You're mixing up the various phases of a clinical trial. Phases 1 and 2 are as you describe and are looking specifically at adverse reactions. By the time it gets to Phase 3 (ie this one) they know what any severe reactions or side-effects might be....pace the Oxford trial that was briefly halted. What they are looking at in Phase 3 is the efficacy. In other words, how many of the 10,000 recruited develop Covid (or not). It is very hard, clearly, particularly as they have no metrics as to the individual circumstances of each participant. In other words, does their lifestyle make them more exposed than, say, someone like me who is effectively self-isolating. It's a numbers game. But then all clinical trials are these days.

[Anastasius]

As one who falls into the latter category, I would be prepared to put myself forward, provided the scheme had been going for a good month, and reports were that it was safe.

That is what Phase 1 and 2 are all about. So this is Phase 3.

[Anastasius]

Your constraints probably mean that in practice it would be at least 4-6 months in from the start of the trial, possibly longer. Is it possible to seriously establish safety within 3 months? Also, what might be considered safe for a 30 year old fit person may be less appropriate for a 70+ year old with medical problems. It may not be so easy to extrapolate from younger people to older ones, though that of course is what is likely to happen. Some older people who are perhaps already ill may feel public spirited, and go for it on the grounds that they possibly won't get a lot worse, and they may feel they've not got so much to lose. It'd be quite interesting to know what would motivate people in different groups to put themselves forward.

Wrong. Wrong and wrong again. As responded to above. And they don't just take any Tom, Dick or Harry, for christ sake. They do actually screen participants.

Jeez.....why did I bother ?

[french frank]

And they don't just take any Tom, Dick or Harry, for christ sake. They do actually screen participants.

If they fed all the patient medical data into a computer and it came up with my name as a possible 'recruit', I would only ask out of interest what it was about me that made me suitable. Then I'd agree.

[Anastasius]

They don't have access to your medical details, FF..