The left handed piano was partly made for music psychology studies, I met someone involved with it a few years ago and they were telling me how they were using it to study how the brain learns and responds to change.
As far as guitars are concerned, it is surely absolutely standard for string instruments to have the bass strings at the top (or on the left for the viol/in family)? The concept of 'up' isn't the layout of the strings but going up the fingerboard towards the bridge.
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